Encefalitis antiNMDA simulando neuromielitis óptica seronegativa


Features of atypical anti-NMDA receptor encephalitis
MRI: (A) Initial contrast-enhancing lesion; (B) longitudinally extensive transverse myelitis; (C) continued development of contrast-enhancing lesions; (D) retrochiasmatic optic neuritis; (E, F) continued accumulation of T2/fluid-attenuated inversion recovery (FLAIR) hyperintense lesion burden, with sagittal FLAIR hyperintensities reminiscent of Dawson's fingers (E). Brain biopsy (from contrast-enhancing frontal lobe lesion): (G) perivascular infiltrate with associated reactive microgliosis; (H) widespread parenchymal destruction mediated by infiltrative lymphocytes and macrophages without selective demyelination; (I) prominent mixed perivascular infiltrate (macrophages, T- and B-lymphocytes with uncommon neutrophils and rare eosinophils). Western blot: (J) Western blot depicting the presence of several additional serum-derived autoantibodies reactive against cerebellar protein extract from control human brain.


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